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KMID : 0388120080170020065
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Journal of Korean Society for the Study of Obesity
2008 Volume.17 No. 2 p.65 ~ p.72
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Relationship between AHI and Insulin Resistance, Serum Adiponectin, and Visfatin
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Suh Young-Sung
Ahn Byung-Hoon
Cho Yong-Won
Hwang Sang-Hee
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Abstract
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Background: Obstructive sleep apnea (OSA) is closely related to insulin resistance. Adipocytokines, adiponectin and visfatin, may induce the development of insulin resistance among OSA patients. Therefore, we examined the relationships between apnea-hypopnea index (AHI) and insulin resistance; between AHI and adiponectin; and between AHI and visfatin in Korean snoring subjects.
Methods: Eighty one adult habitual snorers who visited the hospital for an examination of polysomnography were divided into either simple snorers (AHI < 5), mild OSA subjects(AHI 5 < or = to < 15), or moderate and severe OSA subjects (AHI > or = 15). Anthropometric data were measured. The serum adiponectin, visfatin, and insulin were measured. Insulin resistance was measured as homeostasis model assessment (HOMA-IR).
Results: After adjusting for age, sex and waist circumference (WC), insulin, HOMA-IR, and adipocytokines were not different among the subgroups. Fasting insulin level and HOMA-IR were positively correlated with body mass index (BMI), WC, hip circumference (HC) and AHI. In addition, HOMA-IR was positively correlated with age. The serum adiponectin level was inversely associated with WC and AHI but positively associated with sex. The serum level of visfatin was negatively correlated with sex. Stepwise multiple regression analysis indicated that WC was an independent variable of fasting insulin (Adj R2 = 0.340) and HOMA-IR (Adj R2 = 0.322) also WC and sex were independent determinants of adiponectin level (Adj R2 = 0.161). Sex was shown to be a predictor of visfatin level (Adj R2 = 0.039).
Conclusion: Waist circumference was found to be independently associated with insulin resistance among the snoring subjects. However, AHI did not serve as a predictor of adiponectin and visfatin
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KEYWORD
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AHI, Snoring, Insulin resistance, Vesfatin, Adiponectin
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